| Jugador |
Equipo |
Goles |
| Güiza |
Mallorca |
27 |
| Luis Fabiano |
Sevilla |
24 |
| Agüero |
At. Madrid |
19 |
| Nihat |
Villarreal |
18 |
| Raúl |
Real Madrid |
18 |
| Villa |
Valencia |
18 |
| Oliveira |
Zaragoza |
17 |
| Eto´o |
Barcelona |
16 |
| Forlán |
At. Madrid |
16 |
| Kanouté |
Sevilla |
16 |
| Llorente |
Valladolid |
16 |
| Van Nistelrooy |
Real Madrid |
16 |
| Diego Milito |
Zaragoza |
15 |
| Luis García |
Espanyol |
13 |
| Negredo |
Almería |
13 |
| Arango |
Mallorca |
12 |
| Edu |
Betis |
12 |
| Henry |
Barcelona |
12 |
| Robinho |
Real Madrid |
11 |
| Rossi |
Villarreal |
11 |
| Bojan |
Barcelona |
10 |
| Iván Alonso |
Murcia |
10 |
| Llorente |
Athletic Club |
10 |
| Messi |
Barcelona |
10 |
| Sinama Pongolle |
Recreativo de Huelva |
10 |
| Tamudo |
Espanyol |
10 |
| Sneijder |
Real Madrid |
9 |
| Víctor |
Valladolid |
9 |
| Xisco |
Deportivo de La Coruña |
9 |
| Guille Franco |
Villarreal |
8 |
| Higuaín |
Real Madrid |
8 |
| Maxi Rodríguez |
At. Madrid |
8 |
| Pavone |
Betis |
8 |
| Riga |
Levante |
8 |
| Ronaldinho |
Barcelona |
8 |
| Aduriz |
Athletic Club |
7 |
| Albín |
Getafe |
7 |
| Dady |
Osasuna |
7 |
| Felipe Melo |
Almería |
7 |
| Manu del Moral |
Getafe |
7 |
| Simao |
At. Madrid |
7 |
| Tchité |
Racing de Santander |
7 |
| Xavi |
Barcelona |
7 |
| Baiano |
Murcia |
6 |
| Carlos Martins |
Recreativo de Huelva |
6 |
| Jorge López |
Racing de Santander |
6 |
| Mark González |
Betis |
6 |
| Morientes |
Valencia |
6 |
| Abel |
Murcia |
5 |
| Camuñas |
Recreativo de Huelva |
5 |
| Cazorla |
Villarreal |
5 |
| Duscher |
Racing de Santander |
5 |
| Geijo |
Levante |
5 |
| Guardado |
Deportivo de La Coruña |
5 |
| Ibagaza |
Mallorca |
5 |
| Javi Guerrero |
Recreativo de Huelva |
5 |
| Mata |
Valencia |
5 |
| Munitis |
Racing de Santander |
5 |
| Riki |
Deportivo de La Coruña |
5 |
| Sergio |
Deportivo de La Coruña |
5 |
| Sergio Ramos |
Real Madrid |
5 |
| Varela |
Mallorca |
5 |
| Webó |
Mallorca |
5 |
| Borja Valero |
Mallorca |
4 |
| Casquero |
Getafe |
4 |
| Coloccini |
Deportivo de La Coruña |
4 |
| De Lucas |
Murcia |
4 |
| Etxeberria |
Athletic Club |
4 |
| Gabilondo |
Athletic Club |
4 |
| Jesús Navas |
Sevilla |
4 |
| Keita |
Sevilla |
4 |
| Marco Rubén |
Recreativo de Huelva |
4 |
| Plasil |
Osasuna |
4 |
| Riera |
Espanyol |
4 |
| Robben |
Real Madrid |
4 |
| Senna |
Villarreal |
4 |
| Sergio García |
Zaragoza |
4 |
| Sesma |
Valladolid |
4 |
| Silva |
Valencia |
4 |
| Smolarek |
Racing de Santander |
4 |
| Sobis |
Betis |
4 |
| Susaeta |
Athletic Club |
4 |
| Uche |
Getafe |
4 |
| Valdo |
Espanyol |
4 |
| Baptista |
Real Madrid |
3 |
| Braulio |
Getafe |
3 |
| Giovani |
Barcelona |
3 |
| Iván Bolado |
Racing de Santander |
3 |
| Kalu Uche |
Almería |
3 |
| Mati Fernández |
Villarreal |
3 |
| Pedro León |
Levante |
3 |
| Ramis |
Mallorca |
3 |
| Saviola |
Real Madrid |
3 |
| Sola |
Osasuna |
3 |
| Sousa |
Getafe |
3 |
| Tomasson |
Villarreal |
3 |
| Xisco |
Betis |
3 |
|
